The Religious of the Sacred Heart of Mary began teaching local young women in 1923 after opening Marymount-in-the-West School. Having been invited by Bishop John Cantwell, seven sisters of the Religious of the Sacred Heart of Mary, under the leadership of Mother Cecilia Rafter, R.S.H.M., formed what was first an elementary school and, shortly thereafter, a high school. Within ten years, many young women wished to continue their education with the R.S.H.M. beyond high school and Marymount Junior College opened as an all-women's school on the Westwood campus of Marymount High School in 1933. Mother Gertrude Cain, R.S.H.M., served as the first president of the junior college and guided its development into a four year college in the 1947-48 academic year, assuming the name Marymount College of Los Angeles. In 1960, having outgrown its shared Westwood campus, Marymount College moved both its two year program and its four year program to the Palos Verdes Peninsula in southwestern Los Angeles.
By the mid 1960s, Loyola University of Los Angeles had unsuccessfully petitioned the Archbishop of Los Angeles, Cardinal James Francis McIntyre to allow coeducation at Loyola for several years. In 1966, Raymunde McKay, R.S.H.M., president of Marymount College, began discussions with Charles Casassa, S.J., president of Loyola University, and Cardinal McIntyre to begin an affiliation between Loyola and Marymount. The cardinal agreed to the arrangement and it was announced that in 1968 Marymount College would move its four-year program to Loyola's Westchester campus. Simultaneously, President McKay and Mary Felix Montgomery, C.S.J., began talks of merging Marymount College and St. Joseph College of Orange. In 1968 Marymount and St. Joseph Colleges merged under the Marymount name with an agreement that the traditions and heritage of both the Religious of the Sacred Heart of Mary and Sisters of St. Joseph of Orange would be carried in the Marymount name. As part of the Marymount College Agreement, Marymount College was administered "co-equally" by the R.S.H.M. and Sisters of St. Joseph as members of both communities partnered in the governing, staffing, and teaching of Marymount College under President McKay's leadership. Subsequently, St. Joseph College of Orange was renamed Marymount College of Orange.
As Marymount and Loyola began their affiliation on Loyola's campus in 1968, the Sisters of St. Joseph joined the R.S.H.M. in this venture. For five years, Loyola and Marymount remained separate institutions, sharing facilities and faculties. In 1973, the two institutions merged into Loyola Marymount University. President Donald Merrifield, S.J., who had been serving as president of Loyola University, remained president of LMU and Renée Harrangue, R.S.H.M., who had been the academic vice president at Marymount, was named provost. The R.S.H.M. sisters lived on campus first in the Marymount Dorm (now known as Raymunde McKay, R.S.H.M., Hall) for a year and then in the Thomas and Dorothy Leavey Center. In 1999, the R.S.H.M. gifted the Leavey Center to the University and moved into several housed in the Westchester neighborhood. Since the merger, the Religious of the Sacred Heart of Mary have continued to partner with the Jesuits, Sisters of St. Joseph, other religious on campus, and countless dedicated lay colleagues in furthering the mission of LMU as one of its sponsoring religious orders.